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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsPre-Analytical Framework for Routine Clinical Use of Liquid Biopsies: Combining EVs and cfDNA
Liquid biopsies hold significant potential for the non-invasive diagnostics of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062837 | Pride
Extracellular vesicles Liquid biopsy Cfdna Human plasma Tube preservation Isolation protocol Pre-analytics Translation 
ProteomicsA translational protocol for the analysis of plasma-derived extracellular vesicle proteomics
We establish here an EV purification and proteomic analysis workflow in a real world clinical setting in which we evaluate different variables, from blood collection through protein preparation for mass spectrometry (MS). We compare blood collection tubes, sample transportation and storage condition...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058373 | Pride
Protocol Proteomics Preanalytics Liquid biopsy Plasma Extracellular vesicles Translation 
TranscriptomicsGene expression in hypoxic non-small cell lung cancer
Hypoxia triggers aggressive cancer growth and contributes to chemotherapy resistance. Novel therapeutic strategies aim at targeting hypoxia activated signaling pathways. Tumor hypoxia not only affects neoplastic tumor cells but also the surrounding stroma cells. Therefore, a novel ex vivo model was ...
ORGANISM(S): Homo sapiens 
2011-07-27 | E-GEOD-30979 | biostudies-arrayexpress
TranscriptomicsHuman bone and marrow niche formation by mesenchymal progenitors in vivo is predefined by an organotypic epigenetic signature
In this study, we have analyzed DNA methylation characteristics of human mesenchymal stem and progenitor cells (MSPCs) form different tissue sources including bone marrow (BM), white adipose tissue (WAT ), umbilical cord (UC) as well as dermal fibroblasts by using the HumanMethylation450K array. Cel...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-41933 | biostudies-arrayexpress
UnknownENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.
Not available
S-EPMC8805695 | biostudies-literature
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