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ProteomicsSLC12A3 isoforms in human urine exosomes
The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. Human SLC12A3 gene encoding NCC gives rise to three isoforms. Only the isoform 3 has been extensively investigated. The goal of the present study was, therefore, to determine the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080722 | MassIVE
ProteomicsProtein profile of vitreous from Reeler model
To provide information about candidate factors contributing to impaired retinogenesis that might be useful tool for alternative therapeutic strategies, proinflammatory/profibrogenic mediator were evaluated in the vitreous from Reelin deficient mice, a model characterized by impaired retinogenesis. V...
ORGANISM(S): Mus musculus 
2019-02-13 | E-MTAB-7622 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human bronchoalveolar lavage and lung biopsy samples in the segmental endotoxin challenge model
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy can be used as a model to safely induce transient airway inflammation in the human lung. The LPS challenge model enables investigation of cellular mechanisms involved in pulmonary inflammatory processes as well as pharmacodynamic ana...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13318 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of primary visceral adipocytes isolated from wildtype mice or mice with adipocyte specific deletion of Atg7
Genes involved in the autophagic pathway are risk factors for the development of inflammatory bowel disease. In addition, patients with Crohn’s disease exhibit a profound expansion of mesenteric fat during the pathology. We investigated in our study the role of autophagy in mature adipocyte during i...
ORGANISM(S): Mus musculus 
2023-01-14 | E-MTAB-12498 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support
Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are avail...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-21610 | biostudies-arrayexpress
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