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TranscriptomicsERK signaling regulates opposing functions of JUN family transcription factors in prostate cancer cell migration
Knockdowns of c-JUN and JUND had opposite effects on PC3 prostate cell migration. We predicted that c-JUN and JUND control the same set of cell migration genes, but in opposite directions. To test this hypothesis, mRNA with expression changes in c-JUN and JUND knockdown PC3 cell lines were compared ...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-53470 | biostudies-arrayexpress
GenomicsOncogenic ETS proteins replace activated Ras/MAPK signaling in prostate cells.
Approximately 50% of prostate cancers have chromosomal translocations resulting in the over-expression one of four ETS family transcription factors. However, it is not known why these four four family members are selected for oncogenic roles, while other ETS proteins are not. We found that the four...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-29808 | biostudies-arrayexpress
TranscriptomicsETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells (RNA-Seq)
ETS1 and RAS/ERK regulate a common gene expression program in establishing enviroment suitable for prostate cancer cell migration. mRNA profiles of luciferase knockdown (WT), ETS1 knockdown, and U0126 treated DU145 cells were generated using deep sequencing, in triplicate, using Illumina HiSeq. Knoc...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-59020 | biostudies-arrayexpress
TranscriptomicsOncogenic ETS proteins regulate a Ras/MAPK gene expression program in the absence of MAPK signaling
Approximately 50% of prostate cancers have chromosomal translocations resulting in the over-expression one of four ETS family transcription factors. However, it is not known why these four four family members are selected for oncogenic roles, while other ETS proteins are not. We found that the four...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-29438 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis reveals determinants of redundant and specific binding within a transcription factor family
A central question in transcription factor biology is how a specific member of a transcription factor family occupies a promoter in vivo, when all family members bind the same consensus site in vitro. To uncover the mechanisms regulating DNA binding specificity within transcription factor families,...
ORGANISM(S): Homo sapiens 
2007-07-27 | E-GEOD-7449 | biostudies-arrayexpress
TranscriptomicsRNA Pol III transcriptomes and relationships to Pol II promoters, enhancer-binding factors and chromatin domains
RNA polymerase III transcribes many noncoding RNAs (e.g. tRNAs) important for translational capacity and other functions. Here, we localized RNA polymerase III, alternative TFIIIB complexes (BRF1/2) and TFIIIC in HeLa cells, determining the Pol III transcriptome, defining gene classes, and reveali...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-20609 | biostudies-arrayexpress
GenomicsHuman RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs) important for translational capacity and other functions. We localized Pol III, alternative TFIIIB complexes (BRF1 or BRF2) and TFIIIC in HeLa cells to determine the Pol III transcriptome, define gene classes and r...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-20309 | biostudies-arrayexpress
GenomicsDNA specificity determinants associate with distinct transcription factor functions
To elucidate how genomic sequences build transcriptional control networks we need to understand the connection between DNA sequence and transcription factor binding and function. Binding predictions based solely on consensus predictions are limited because a single factor can use degenerate sequenc...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-17954 | biostudies-arrayexpress
TranscriptomicsGene expression changes upon knockdown or over-expression of the ETS gene ETV4 in prostate cancer cell lines
Chromosomal abnormalities that give rise to elevated expression levels of the ETS genes ETV1, ETV4, ETV5, or ERG are prevalent in prostate cancer, but the function of these transcription factors in carcinogenesis is not clear. Previous work implicates ERG, ETV1, and ETV5 as regulators of invasive gr...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21209 | biostudies-arrayexpress
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