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TranscriptomicsOncogenic potential of RAS isoforms in melanocytes
We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weak...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6194 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4921 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS part 2
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-5590 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WES
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4917 | biostudies-arrayexpress
GenomicsImmune and Metabolic Features of Brain Metastases Melanoma (Cancer Discovery) Data Access Committee
Data Access Committee EGAC00001001216
EGAC00001001216 | EGA
GenomicsMolecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
There is a critical need to improve our understanding of the pathogenesis of -melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell receptor se...
EGAS00001003672 | EGA
Genomicsba3dbe29-0fd7-4ee5-99b8-d69d3c381e6e - samples
The BAM files for WES and RNA seq used in the article "Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases." on cancer Discovery 2019. PMID: 30787016 PMCID: PMC6497554. Authors : Grant M Fischer, ..., Michael A Davies.
EGAD00001005046 | EGA
TranscriptomicsGene expression profiling of oncogenic NRAS driven mouse melanomas that have developed resistance to NRAS withdrawal
Targeted therapies have the potential to revolutionize cancer care by providing personalized treatment strategies that are less toxic and more effective but it is clear that for most solid tumors suppression of a single target is not sufficient to prevent development of resistance. A powerful method...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-51906 | biostudies-arrayexpress
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