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TranscriptomicsRNAPII CTD dataset
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction and mRNA expression analysis we found that truncating the CTD resulted in distinct changes to cellular function. Truncating th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-13 | E-GEOD-43120 | biostudies-arrayexpress
TranscriptomicsCtk1 + CTD mutants
Transcription termination in Saccharomyces cerevisiae can be performed by at least two distinct pathways and is directed by the phosphorylation status of the carboxy-terminal domain (CTD) of RNA polymerase II (Pol II). Late termination of mRNAs is performed by the CPF/CF complex and requires CTD-Ser...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-22 | E-GEOD-40254 | biostudies-arrayexpress
no omics definedTranscription profiling of human hippocampi from epilepsy patients with and without hippocampal sclerosis and autopsy controls
Genome wide gene expression was compared between nonHS, HS temporal lobe epilepsy patients (TLE) and autopsy control hippocampi in a 3-way analysis. In many TLE patients the hippocampus is subject to massive neuronal damage, gliosis and hippocampal sclerosis (HS), while in others there is no apparen...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-MEXP-744 | biostudies-arrayexpress
TranscriptomicsA central role for TFIID in the pluripotent transcription circuitry [PP003]
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
2013-03-21 | E-GEOD-33645 | biostudies-arrayexpress
TranscriptomicsA central role for TFIID in the pluripotent transcription circuitry [PP002]
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
2013-03-21 | E-GEOD-33644 | biostudies-arrayexpress
TranscriptomicscDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype
Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, t...
ORGANISM(S): Canis lupus familiaris 
2007-09-01 | E-GEOD-7659 | biostudies-arrayexpress
TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
TranscriptomicsGS003: Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA.
TATA-binding protein (TBP) is central to the regulation of transcription initiation. Recruitment of TBP to target genes can be positively regulated by one of two basal transcription factor complexes: SAGA or TFIID. Negative regulation of TBP promoter association can be performed by Mot1 or the NC2 c...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-31 | E-GEOD-30148 | biostudies-arrayexpress
TranscriptomicsNO001: Kdm5c controls promoter and enhancer activities
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes like enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is largely unknown how the different methylation stat...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-38862 | biostudies-arrayexpress
TranscriptomicsMH003A:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 1: overexpression of FoxO6
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41554 | biostudies-arrayexpress
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