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TranscriptomicsTranscription profiling of wild type mouse embryonic fibroblasts treated with interferon to study interferon-regulated gene expression.
A number of IFN-induced proteins are believed to be responsible for the antiviral state induced by IFNs. Our microarray analysis of IFN-regulated genes in MEFs from wild-type mice identified 124 probe sets that were differentially regulated upon IFN treatment. This group consisted of many known ISGs...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3400 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profile analysis of the Candida glabrata Pdr1 regulon
The ABC-transporters CgCdr1, CgPdh1, and CgSnq2 are known to mediate azole resistance in the pathogenic fungus Candida glabrata. Activating mutations in CgPDR1, a zinc cluster transcription factor, result in constitutive up-regulation of these ABC-transporter genes but to varying degrees. We examine...
ORGANISM(S): Candida glabrata 
2011-02-21 | E-GEOD-24168 | biostudies-arrayexpress
TranscriptomicsMutation in Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Fluconazole Resistance
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal cla...
ORGANISM(S): Candida albicans 
2008-11-04 | E-GEOD-11320 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression and location analyses of the Candida albicans Tac1p regulon
A major mechanism of azole resistance in Candida albicans is the over-expression of the genes encoding the ABC transporters Cdr1p and Cdr2p. Constitutive over-expression of these efflux pumps is due to mutations in the gene encoding Tac1p, resulting in hyperactivity of this zinc cluster transcripti...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-8727 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between critically ill trauma patients who do and do not go on to develop ventilator-associated pneumonia
Objective: Identify genes that are differentially expressed between critically ill trauma patients who go on to develop ventilator-associated pneumonia (VAP) compared to similar patients who do not develop VAP Using gene expression differences, develop a model that predicts which patients are at gre...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-30385 | biostudies-arrayexpress
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