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Transcriptomicsleukemia propagating cells rebuild an evolving niche in response to therapy
Residence of cancer-propagating cells (CPCs) within preferential microenvironmental niches has a major part in evading therapy. However, the nature of niches involved and the mechanisms protecting CPCs remain largely unknown. We addressed these issues in mouse transplantation models of acute lymphob...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-56273 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cells, pro-B cells and TEL-AML1 tranduced cord blood cells to study TEL-AML1 associated childhood leukemia
The microarray data presented here relate to a study on TEL-AML1 associated childhood leukemia (Hong et al, 2008) the abstract of which is as follows:

"Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framew...
ORGANISM(S): Homo sapiens 
2008-01-20 | E-MEXP-1403 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD133-positive G0 and G1 human ubmbilical vein cells
To identify regulators of human HSC fate, we transcriptionally profiled quiescent primitive cord blood (CB) CD133+ G0 cells enriched for long term culture initiating cell (LTC-IC) activity. CD133+ G0 cells were sorted by cell cycle status using combined DNA and RNA staining; less immature CD133+G1 c...
ORGANISM(S): Homo sapiens 
2008-03-06 | E-MEXP-1412 | biostudies-arrayexpress
ProteomicsSIRT2 regulates extracellular vesicle-mediated liver-bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits ...
ORGANISM(S): Mus Musculus 
PXD041145 |
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