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Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient blood flow to the brain to meet metabolic demand, and results in brain tissue death (cerebral infarction) due to poor oxygen supply (cerebral hypoxia). Our group is interested in the protective effects of ne...
ORGANISM(S): Mus musculus 
Our group has been systematically investigating effects of the neuropeptide pituitary adenylate-cyclase activating polypeptide (PACAP) on the ischemic brain. To do so, we have established and utilizing the permanent middle cerebral artery occlusion (PMCAO) mouse model, where PACAP38 (1 pmol) injecti...
ORGANISM(S): Mus musculus 
The changes of mRNA expression levels were analyzed in striatum, salivary glands , and peripheral leukocyte of the juvenile rat stimulated by tickling for 4 weeks as a positive stimulation. Keywords: Stress response Twenty-one-day-old male Wistar ratsM-cM-^@M-^@after weaning were used. All rats wer...
ORGANISM(S): Rattus norvegicus 
The present study aimed to examine the effect of high-fat diet prior to pregnancy on the liver of mouse offspring. Female C57BL/6J mice were fed a normal chow (15.2% fat by energy) (CTR and CTR-PP groups) or a high-fat chow (31.2% fat by energy) (HFD and HFD-PP groups) for 3−4 weeks and then mated w...
ORGANISM(S): Mus musculus 
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is considered to be a potential therapeutic agent for prevention of cerebral ischemia. Ischemia is a most common cause of death after heart attack and cancer causing major negative social and economic consequences. - This st...
ORGANISM(S): Mus musculus 
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