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TranscriptomicsUnraveling the Specific Ischemic Core and Penumbra Transcriptome in Permanent Middle Cerebral Artery Occlusion Model Mice Brain Treated with Neuropeptide PACAP38
Our group has been systematically investigating effects of the neuropeptide pituitary adenylate-cyclase activating polypeptide (PACAP) on the ischemic brain. To do so, we have established and utilizing the permanent middle cerebral artery occlusion (PMCAO) mouse model, where PACAP38 (1 pmol) injecti...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-62884 | biostudies-arrayexpress
TranscriptomicsDNA Microarray Analysis Approach for Unraveling the Ischemic Mouse Brain Transcriptome
Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient blood flow to the brain to meet metabolic demand, and results in brain tissue death (cerebral infarction) due to poor oxygen supply (cerebral hypoxia). Our group is interested in the protective effects of ne...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-28201 | biostudies-arrayexpress
TranscriptomicsTranscriptomics and Proteomics Analyses of the PACAP38 influenced Ischemic Brain in Permanent Middle Cerebral Artery Occlusion Model Mice
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is considered to be a potential therapeutic agent for prevention of cerebral ischemia. Ischemia is a most common cause of death after heart attack and cancer causing major negative social and economic consequences. - This st...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-37565 | biostudies-arrayexpress
TranscriptomicsPotential of Neuropeptide PACAP38 Therapy for Brain Ischemia: Insights from Bioinformatics Analysis of the High-throughput DNA Microarray Analyses Data in PMCAO Mouse Model using Ischemic Core and Penumbra Transcriptomic Data
Permanent middle cerebral artery occlusion (PMCAO) mouse model has been established and used by our group with a focus on systematically investigating effects of the neuropeptide pituitary adenylate-cyclase activating polypeptide (PACAP38) on the ischemic brain. Using an intracerebroventrically PACA...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-67421 | biostudies-arrayexpress
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