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ProteomicsHORMAD1 interactome by affinity purification-mass spectrometry
HORMAD1 is aberrantly expressed in 60% of triple-negative breast cancers and associates with signatures of genomic instability. Aberrant expression of HORMAD1 in mitotic cells leads to defects in spindle assembly checkpoint. HORMAD1 affinity purification-mass spectrometry interactome mapping in mito...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD023666 | Pride
Breast cancer Mitosis Spindle assembly checkpoint Hormad1 Aurora b 
TranscriptomicsHORMAD1 mutation disrupts synaptonemal complex formation and chromosomal segregation in fertilized eggs
Hormad1 encodes a protein that contains a HORMA domain, and unlike Mad2, Hormad1 expression is germ cell specific. We discovered that both male and female are infertile, and HORMAD1 has important function in synaptonemal complex formation, sex chromosome inactivation during spermatogenesis and chrom...
ORGANISM(S): Mus musculus 
2010-04-27 | GSE21524 | GEO
GenomicsRNA-sequencing of testes from control and Hormad1&2SFB/SFB mice
RNA-sequencing of testes from control and Hormad1&2SFB/SFB mice
PRJNA1146735 | ENA
UnknownHormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.
Not available
S-EPMC2973818 | biostudies-literature
UnknownEpigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivity.
Not available
S-EPMC6059019 | biostudies-literature
UnknownFunctional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance.
Not available
S-EPMC9355871 | biostudies-literature
UnknownHORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Not available
S-EPMC8165579 | biostudies-literature
UnknownEctopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas.
Not available
S-EPMC10296909 | biostudies-literature
UnknownThe Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Not available
S-EPMC6192992 | biostudies-literature
GenomicsEffect of HORMAD1 and CT83 Cancer/Testis Gene expression on human mammary epithelial cell line (HMLE)
Effect of HORMAD1 and CT83 Cancer/Testis Gene expression on human mammary epithelial cell line (HMLE)
PRJNA981500 | ENA
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