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MetabolomicsLipidomics of hormone-sensitive lipase variants
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ORGANISM(S): Homo sapiens 
ST000662 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse soleus muscle from hormone sensitive lipase-null animals
Expression analysis in order to elucidatethe role of hormone-sensitive lipase in soleus muscle.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1772 | biostudies-arrayexpress
ProteomicsImpact of hormone-sensitive lipase depletion on adipocyte secretome
Hormone-sensitive lipase (HSL) is an enzyme involved in the breakdown of triacylglycerols into fatty acids, a catabolic pathway called lipolysis. Out of all mammalian cells, adipocytes express the highest levels of HSL. To explore the roles of HSL beyond adipocyte lipolysis, we performed transcript...
ORGANISM(S): Homo sapiens (Human) 
2026-01-30 | PXD029261 | Pride
Obesity Adipocyte Hormone-sensitive lipase Extracellular matrix 
GenomicsTranscriptomic analyses of hMADS cells depleted for hormone-sensitive lipase
Transcriptomic analyses of hMADS cells depleted for hormone-sensitive lipase
PRJNA774345 | ENA
ProteomicsNuclear hormone-sensitive lipase controls adipocyte function
Hormone-sensitive lipase (HSL) is a neutral lipase which hydrolyses fat stored as triacylglycerols in adipocyte lipid droplets. Its activity is under the control of hormones and neurotransmitters through protein kinase (PK)-mediated phosphorylation. Here we show that HSL is expressed in the nucleus ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-30 | PXD043860 | Pride
Obesity Adipocyte Hormone-sensitive lipase Protein-protein interaction Adipose tissue 
TranscriptomicsTranscription profiling of mouse liver samples comparing hormone sensitive lipase (HSL) knockout mice vs. wildtype
HSL is a key enzyme in in the mobilization of fatty acids from the triglyceride stores of white adipose tissue. In addition, it is expressed in mice liver. In the present microarray study, changes in the transcript profile of murine liver samples due to global HSL knockout were investigated. Experi...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-10067 | biostudies-arrayexpress
MetabolomicsMetabolomics Workbench ST000662 - GNPS - Lipidomics of hormone-sensitive lipase variants
The samples are frozen biopsies of whilte subcutaneous adipose tissues (50 mg). Samples were collected from 4 hormone-sensitive lipase (HSL) WT patients (adipose insulin sensitive), 3 HSL heterozygote patients and 1 HSL KO patient.
ORGANISM(S): Homo Sapiens 
2018-08-02 | MSV000082691 | GNPS
TranscriptomicsTranscriptomic analyses of hMADS cells depleted for hormone-sensitive lipase
Hormone-sensitive lipase HSL is a major metabolic enzyme of adipocyte as the rate limiting enzyme of lipolysis. Recently, a non enzymatic role of HSL as been described in the regulation of the Carbohydrate Responive Element Binding Protein (ChREBP), controlling adipocyte insulin sensitivity. We aime...
ORGANISM(S): Homo sapiens 
2025-10-25 | GSE186544 | GEO
TranscriptomicsTranscription profiling of liver from PPARalpha knockout mice: PPARa -dependent regulation of hepatic lipid metabolism by expression profiling (GEO Super series)
This SuperSeries is composed of the following subset Series:; GSE8290: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 1; GSE8291: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 2...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat livers with inactivated PPARI
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8302 | biostudies-arrayexpress
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