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TranscriptomicsTranscription profiling of brain from mice with ischemia of the right common carotid artery or sham treated and then exposed to hypoxic conditions
Animals were anaesthetized with halothane (4% in 70% N2O: 30% O2). A small incision was made in the neck and the right common carotid artery was exposed and ligated with 4-0 surgical silk in three separate locations. The incision was closed, and the animal allowed to recover with access to food an...
ORGANISM(S): Mus musculus 
2007-11-13 | E-MEXP-1253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat cortex regions
The neocortex of the mammalian brain is comprised by six distinct layers with neuronal subtypes that appear indistinguishable from one cortical area to the next. Correspondingly, global gene expression seems to be almost identical across the cerebral cortex and only a few genes have so far been repo...
ORGANISM(S): Rattus norvegicus 
2010-12-31 | E-TABM-1019 | biostudies-arrayexpress
TranscriptomicsA survey of human brain transcriptome diversity at the single cell level
We used single cell RNA sequencing on 466 cells to capture the cellular complexity of the adult and fetal human brain at a whole transcriptome level. Healthy adult temporal lobe tissue was obtained from epileptic patients during temporal lobectomy for medically refractory seizures. We were able to c...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-67835 | biostudies-arrayexpress
TranscriptomicsDual leucine zipper kinase is required for excitotoxicity induced neuronal degeneration
To investigate the role of DLK in the adult brain, we generated mice in which excision of the DLK allele can be temporally controlled to avoid the lethality observed at early postnatal ages in DLK null mice (Hirai et al., 2006). This was done by crossing mice with DLK exons 2-5 flanked by loxP sites...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-50245 | biostudies-arrayexpress
UnknownObesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Not available
S-EPMC6911092 | biostudies-literature
TranscriptomicsMicroarray profiling of polyploid macrophage progeny
To explore how bacterial lipoproteins (i.e. TLR2 ligands) increased macrophage ploidy via mitotic defects, we performed global analysis of cell cycle gene expression changes induced by bacterial lipoproteins. FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of th...
ORGANISM(S): Mus musculus 
2016-10-27 | E-MTAB-5085 | biostudies-arrayexpress
UnknownA randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease.
Not available
S-EPMC3324323 | biostudies-literature
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
UnknownMutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.
Not available
S-EPMC2677501 | biostudies-literature
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