Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lore Becker
PROVIDER: E-GEOD-13588 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20090501 5
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene of mice. Although these mice are generally healthy, they have qualitatively different ultrasonic vocalizations, decreased exploratory behavior and decreased dopamine concentrations in the brain suggesting that the humanized Foxp2 allele a ...[more]