Dataset Information


Synaptosome proteome IGF2 enhancer knockout mice

ABSTRACT: We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic nerve terminal)by mass spectometry from WT and Igf2 enhancer KO mice.


ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: Bryan Killinger  

LAB HEAD: Viviane Labrie

PROVIDER: PXD012786 | Pride | 2019-05-31


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Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis.

Pai Shraddha S   Li Peipei P   Killinger Bryan B   Marshall Lee L   Jia Peixin P   Liao Ji J   Petronis Arturas A   Szabó Piroska E PE   Labrie Viviane V  

Nature communications 20190503 1

Impaired neuronal processes, including dopamine imbalance, are central to the pathogenesis of major psychosis, but the molecular origins are unclear. Here we perform a multi-omics study of neurons isolated from the prefrontal cortex in schizophrenia and bipolar disorder (n = 55 cases and 27 controls). DNA methylation, transcriptomic, and genetic-epigenetic interactions in major psychosis converged on pathways of neurodevelopment, synaptic activity, and immune functions. We observe prominent hypo  ...[more]

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