Proteomics

Dataset Information

0

Synaptosome proteome IGF2 enhancer knockout mice


ABSTRACT: We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic nerve terminal)by mass spectometry from WT and Igf2 enhancer KO mice.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: Bryan Killinger  

LAB HEAD: Viviane Labrie

PROVIDER: PXD012786 | Pride | 2019-05-31

REPOSITORIES: pride

altmetric image

Publications

Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis.

Pai Shraddha S   Li Peipei P   Killinger Bryan B   Marshall Lee L   Jia Peixin P   Liao Ji J   Petronis Arturas A   Szabó Piroska E PE   Labrie Viviane V  

Nature communications 20190503 1


Impaired neuronal processes, including dopamine imbalance, are central to the pathogenesis of major psychosis, but the molecular origins are unclear. Here we perform a multi-omics study of neurons isolated from the prefrontal cortex in schizophrenia and bipolar disorder (n = 55 cases and 27 controls). DNA methylation, transcriptomic, and genetic-epigenetic interactions in major psychosis converged on pathways of neurodevelopment, synaptic activity, and immune functions. We observe prominent hypo  ...[more]

Similar Datasets

2017-09-25 | PXD005634 | Pride
2014-11-17 | PXD001375 | Pride
2017-07-17 | MSV000081339 | MassIVE
2013-04-18 | E-GEOD-44764 | ArrayExpress
2013-08-12 | E-MTAB-1644 | ArrayExpress
2019-07-16 | PXD010822 | Pride
2013-06-01 | E-GEOD-47128 | ArrayExpress
2015-10-23 | E-GEOD-74257 | ArrayExpress
2012-06-01 | E-MTAB-1001 | ArrayExpress
| GSE89136 | GEO