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TranscriptomicsDeciphering myeloma risk loci by eQTL analysis
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) at 7 loci influencing multiple myeloma (MM) risk. We generated expression quantitative trait loci (eQTL) data on malignant plasma cells from two patient series (totaling 848) to fine map the risk loci assoc...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-MTAB-2299 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells from patients with smoldering multiple myeloma
Gene expression profiling of CD138 purified bone marrow plasma cells of patients with smoldering multiple myeloma
ORGANISM(S): Homo sapiens 
2023-05-31 | E-MTAB-4743 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells, CD27 memory B-cells, polyclonal plasmablastic cells and human myeloma cell lines
Gene expression profiling of CD138 purified bone marrow plasma cells of healthy donors, CD27 memory B-cells, cultured ployclonal plasmablastic cells and cultured human myeloma cell lines. Samples from healthy donors have been re-used from ArrayExpress experiment E-MEXP-2360. Some of the myeloma cell...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5212 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bome marrow plasma cells from patients with mutliple myeloma or monoclonal gammopathy of unknown significance
Gene expression profiling of CD138 purified bone marrow plasma cells of previously untreated multiple myeloma patients and individual with monoclonal gammopathy of unknown significance (MGUS)
ORGANISM(S): Homo sapiens 
2010-08-09 | E-MTAB-317 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Multiple Myeloma - Reporting of Entities, Risk and Targets in Clinical Routine
Gene expression profiling of CD138 purified bone marrow plasma cells of previoulsy untreated multiple myeloma patients and individuals with monoclonal gammopathy of uncertain significance (MGUS)
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-372 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow plasma cells from 320 newly diagnosed multiple myeloma patients
In order to identify relevant, molecularly defined subgroups in Multiple Myeloma (MM), gene expression profiling (GEP) was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/ GMMG-HD4 trial using Affymetrix Gene Chip U133 p...
ORGANISM(S): Homo sapiens 
2010-06-27 | E-GEOD-19784 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Epigenetic modulating agents are under intense investigation for cancer therapy including multiple myeloma. In this study, we investigated the in vivo transcriptional response to epigenetic modulating agents in multiple myeloma using the 5T33MM model with the aim to identify potential clinical rele...
ORGANISM(S): Mus musculus 
2018-02-26 | E-MTAB-3178 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testis, primary myeloma cell and normal tissue samples to identify novel cancer-testis genes
Cancer-testis (CT) antigens are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression ...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-MTAB-81 | biostudies-arrayexpress
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