Transcriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 418 [Affymetrix]
ORGANISM(S): Mus musculus
SUBMITTER: Ken Maes
PROVIDER: E-MTAB-3178 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma.
Maes Ken K De Smedt Eva E Kassambara Alboukadel A Hose Dirk D Seckinger Anja A Van Valckenborgh Els E Menu Eline E Klein Bernard B Vanderkerken Karin K Moreaux Jérôme J De Bruyne Elke E
Oncotarget 20150201 5
Histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors (DNMTi) are in early clinical development for multiple myeloma (MM) therapy. Despite all encouraging pre-clinical data, clinical activity of HDACi and DNMTi is mostly lacking. To optimize the trials, characterization of the in vivo response towards HDACi and DNMTi will be crucial. Therefore, we investigated the transcriptional response after in vivo treatment with the HDACi quisinostat or DNMTi decitabine using the murin ...[more]
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