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MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
MetabolomicsComparing Campylobacter jejuni to three other enteric pathogens in OligoMM 12 mice reveals pathogen-specific host and microbiota responses
Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC and EHEC infection ...
2025-02-25 | MTBLS11078 | MetaboLights
ProteomicsOrientia tsutsugamushi proteome profile host context
Emerging and neglected pathogens pose challenges as their biology is frequently poorly understood, and genetic tools often do not exist to manipulate them. Organism agnostic sequencing technologies offer a promising approach to understand the molecular processes underlying these diseases. Here we ap...
ORGANISM(S): Cellular Organisms 
2020-06-05 | PXD017956 | JPOST Repository
TranscriptomicsHost and pathogen interaction: time course [zebrafish]
The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fis...
ORGANISM(S): Danio rerio 
2013-08-26 | E-GEOD-32118 | biostudies-arrayexpress
TranscriptomicsHost and pathogen interaction: time course [C. albicans]
The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fis...
ORGANISM(S): Candida albicans 
2013-08-26 | E-GEOD-32117 | biostudies-arrayexpress
TranscriptomicsTranscript profiling in Actinobacillus pleuropneumoniae after adherence to, or planktonic growth over, SJPL cells.
Host-pathogen interactions are of great importance in understanding the pathogenesis of infectious microorganisms. We developed in vitro models to study porcine respiratory tract pathogens using an immortalized epithelial cell line, the St. Jude Porcine Lung (SJPL) cell line. In conditions where cy...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2008-07-09 | E-GEOD-12009 | biostudies-arrayexpress
TranscriptomicsHost and pathogen interaction: time course
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Candida albicans 
2013-08-26 | E-GEOD-32119 | biostudies-arrayexpress
MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (MRMS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS811 | MetaboLights
MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (UPLC-MS/MS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS746 | MetaboLights
TranscriptomicsDual RNA-sequencing of nontypeable Haemophilus influenzae and host cell transcriptomes reveals new aspects of host-pathogen interface
Characterization of host-pathogen interactions is critical for the development of next-generation therapies and vaccines. Classical approaches involve the use of transformed cell lines and/or animal models which may not reflect the complexity and response of the human host. We reconstituted the cili...
ORGANISM(S): Haemophilus influenzae 
2015-11-02 | E-GEOD-63900 | biostudies-arrayexpress
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