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TranscriptomicsGenome wide profiling of Su(H) [CSL] binding in Drosophila melanogaster larval CNSs where Notch is hyperactive in neuroblasts for 24 hours
The Notch pathway is a well conserved cell to cell communication mechanism that is normally involved in many developmental processes and when aberrantly activated it leads to diseases such as cancer. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Dros...
ORGANISM(S): Drosophila melanogaster 
2015-12-15 | E-GEOD-68614 | biostudies-arrayexpress
TranscriptomicsChIP-chip time-course from DmD8 cells with Su(H) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the N...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35719 | biostudies-arrayexpress
TranscriptomicsChIP-chip time-course from DmD8 cells with Pol II (Ser 2 and Ser 5 phosphorylated) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the N...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35715 | biostudies-arrayexpress
TranscriptomicsTranscriptional dynamics elicited by a short pulse of Notch activation.
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. Here we have analyzed the temporal changes in transcription following a short Notch activation treatment and have related these to the recruitmen...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35557 | biostudies-arrayexpress
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