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ProteomicsGlycoproteomics analysis of Complement Factor H and its effect on complement regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome
Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of SP-HUS remains poorly understood, and treatment is largely supportive. Complement factor H (FH) is a...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD064837 | Pride
Hemolytic uremic syndrome Glycosylation Streptococcus pneumoniae Glycoproteomics Complement factor h Functional assays 
TranscriptomicsH. pylori infection blocks DNA damage induced apoptosis by T4SS-dependent upregulation of miR-155
The innate immune response against Helicobacter pylori is mainly controlled by pattern recognition receptors that lead to the up-regulation of pro-inflammatory cytokines. A new player in this field is the miR-155 being regulated by TLR ligands in monocytic derived cells influencing certain intracell...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-29388 | biostudies-arrayexpress
ProteomicsHuman testicular matrix - Derivation and characterization of a cytocompatible scaffold from human testis
ITo derive a scaffold from human testis for the purpose of tissue engineering and regenerative medicine, we developed a method to produce a cytocompatible decellularized testicular matrix (DTM) while maintaining the native tissue-specific characteristics and components. The potential benefits of tis...
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001524 | Pride
Testicular structure Extracellular matrix 3d cell culture 
TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human dermal fibroblasts treated with Wnt 3a compared to control cells
human dermal fibroblasts were treated with 100 ng/ml recombinant mouse Wnt 3a for 8 h and 24 h and compared to untreated controls at 8 and 24 h. RNA was isolated and microarray analysis was performed with Illumina Human Sentrix-6 BeadChip arrays
ORGANISM(S): Homo sapiens 
2014-11-26 | E-MTAB-837 | biostudies-arrayexpress
TranscriptomicsSugar turns benefit of cholesterol into immune evasion in Helicobacter pylori infected C57BL/6 mice
Following the initial demonstration of Helicobacter pyloriâ??s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3878 | biostudies-arrayexpress
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
TranscriptomicsCharacterization of the HP1021 regulon of Helicobacter pylori
The genome of the gastric pathogen Helicobacter pylori harbors a remarkably low number of regulatory genes, including three and five open reading frames encoding two-component histidine kinases and response regulators, respectively, which are putatively involved in transcriptional regulation. Inacti...
ORGANISM(S): Helicobacter pylori 
2010-07-01 | E-GEOD-5971 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse line
BACKGROUND: The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, invo...
ORGANISM(S): Mus musculus 
2009-03-01 | E-GEOD-12954 | biostudies-arrayexpress
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