Sugar turns benefit of cholesterol into immune evasion in Helicobacter pylori infected C57BL/6 mice

ABSTRACT: Following the initial demonstration of Helicobacter pyloriâ??s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is stigmatised as mediating detrimental effects in obesity and cardiovascular disease. Since H. pylori is auxotrophic for cholesterol, we explored the assimilation of cholesterol by H. pylori upon infection. Here we show that H. pylori follows a cholesterol gradient and extracts the lipid from plasma membranes of epithelial cells for subsequent glycosylation. Cholesterol promotes phagocytosis of H. pylori by antigen-presenting cells such as macrophages and dendritic cells and enhances antigen-spec

ORGANISM(S): Mus musculus

SUBMITTER: Christian Wunder 

PROVIDER: E-GEOD-3878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress