Interferon-γ-responsive non-hematopoietic cells regulate the immune response to Mycobacterium tuberculosis

ABSTRACT: Immunity to Mycobacterium tuberculosis in humans and in mice requires interferon gamma (IFNγ). Wheras IFNγ has been studied extensively for its effects on macrophages in tuberculosis, we determined that protective immunity to tuberculosis also requires IFNγ-responsive non-hematopoietic cells. Bone marrow chimeric mice with IFNγ-unresponsive lung epithelial and endothelial cells exhibited earlier mortality and higher bacterial burdens than control mice, under-expressed indoleamine-2,3-dioxygenase (Ido1) in lung endothelium and epithelium and over-expressed interleukin-17 (IL-17) with massive neutrophilic inflammation in the lungs. We also found that the products of IDO catabolism of tryptophan selectively inhibit IL-17 production by Th17 cells, by inhibiting the action of IL-23. The

ORGANISM(S): Mus musculus

SUBMITTER: Ludovic Desvignes 

PROVIDER: E-GEOD-19148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress