Mycobacterium marinum chronic infection of adult zebrafish

ABSTRACT: Novel high-throughput deep sequencing technology has dramatically changed the way that the functional complexity of transcriptomes can be studied. Here we report on the first use of this technology to gain insight into the wide range of transcriptional alterations that are associated with an infectious disease process. Using Solexa/IlluminaM-bM-^@M-^Ys digital gene expression (DGE) system, a tag-based transcriptome sequencing method, we investigated mycobacterium-induced transcriptome changes in a model vertebrate species, the zebrafish. Our DGE data substantiate recent RNA-seq results from other models indicating a much larger extent of genome transcription than previously thought, and demonstrate that the host response to bacterial infection adds a further degree of complexity to the tra

ORGANISM(S): Danio rerio

SUBMITTER: Anna Zakrzewska 

PROVIDER: E-GEOD-14782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress