Comparative transcriptional profiling of the lung discriminates S. pneumoniae and Influenza A Virus infections

ABSTRACT: Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated by immune receptors specifically recognizing pathogenic structures serving to elicit a qualitatively and quantitatively adequate immune response. To provide a molecular framework towards a better understanding of the processes relevant in severe infectious pneumonia we performed a transcriptome analysis of lungs from mice infected with S. pneumoniae or Influenza A virus. Overall, we detected 1300 genes that exhibit significant differential expression after infection with either pathogen. Of thos

ORGANISM(S): Mus musculus

SUBMITTER: Andreas Hocke 

PROVIDER: E-GEOD-5289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress