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GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
UnknownEfficacy and safety of JNJ-42165279, a fatty acid amide hydrolase inhibitor, in adolescents and adults with autism spectrum disorder: a randomized, phase 2, placebo-controlled study.
Not available
S-EPMC11631932 | biostudies-literature
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
MetabolomicsImpact of dietary serine and glycine availability on plasma and tissue metabolite composition in mice

This study examines how altering systemic serine and glycine availability through dietary intervention affects breast cancer metastasis in vivo. Female NOD-SCID-gamma (NSG) mice were maintained on either a control amino acid–replete diet or a serine/glycine-enriched diet for two weeks before and ...

2025-12-30 | MTBLS13151 | MetaboLights
MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
ProteomicsPalaeoproteomics of archaeological shell beads
In this project we have applied palaeoproteomics to study archaeological shell beads dating back to the beginning of the 7th mill. cal BCE and recovered from a prehistoric site in Jordan (Ba'ja). These beads were made of mollusc shells and were of unknown origin, but suspected to be made of larger b...
ORGANISM(S): Mollusca 
2024-11-04 | PXD041082 | Pride
Archaeological shells Mollusc shells Ancient proteins Palaeoproteomics Lc-ms/ms 
TranscriptomicsEffect of estrogen and selective estrogen receptor modulators on a mouse model of fallopian tube epithelia, an ovarian cancer precursor
The fallopian tube epithelium is one of the potential sources of high-grade serous ovarian cancer (HGSC). The use of estrogen only hormone replacement therapy increases ovarian cancer risk. Despite estrogenâ??s influence in OVCA, selective estrogen receptor modulators (SERMs) typically demonstrate o...
ORGANISM(S): Mus musculus 
2016-02-08 | E-GEOD-67207 | biostudies-arrayexpress
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
TranscriptomicsWidespread over-expression of the X chromosome in sterile F1 hybrid mice
We used a reciprocal cross of Mus musculus and M. domesticus in which F1 males are sterile in one direction and fertile in the other direction, in order to associate expression differences with sterility. Four different crosses were performed. A cross between two strains within each mouse species (M...
ORGANISM(S): Mus musculus musculus x M. m. domesticus 
2010-10-05 | E-GEOD-17684 | biostudies-arrayexpress
TranscriptomicsRNA-Seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis
We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression ...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-52405 | biostudies-arrayexpress
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