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UnknownDirect inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Not available
S-EPMC4330742 | biostudies-literature
TranscriptomicsToxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into ...
ORGANISM(S): Toxoplasma gondii 
2011-05-25 | E-GEOD-22100 | biostudies-arrayexpress
UnknownMutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.
Not available
S-EPMC5081629 | biostudies-literature
UnknownMutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
Not available
S-EPMC5056035 | biostudies-literature
TranscriptomicsCandidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats
The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol prefere...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15415 | biostudies-arrayexpress
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart from Lmna H222P heterozygous and control mice
The present research is devoted to the identification of gene(s) severely affected by LMNA mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Lmna H222...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6397 | biostudies-arrayexpress
UnknownHigh levels of genomic aberrations in serous ovarian cancers are associated with better survival.
Not available
S-EPMC3553118 | biostudies-literature
TranscriptomicsTranscription profiling of human hepatitis PBMC C patients treated with Peg-interferon alfa-2b plus ribavirin during the first 10 weeks of treatment
Study of PBMC gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntronTM) and ribavirin (administered by weight) in HCV patients. This study compared the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntr...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-11342 | biostudies-arrayexpress
TranscriptomicsHost response and dysfunction in the CNS during chronic simian immunodeficiency virus infection
Molecular basis for CNS dysfunction in simian immunodeficiency virus-infected rhesus monkeys. We used microarrays to identify differentially expressed genes in chronic simian immunodeficiency virus-infected rhesus monkeys. Frontal lobe samples were obtained from control and SIV infected animals for ...
ORGANISM(S): Macaca mulatta 
2012-01-29 | E-GEOD-35397 | biostudies-arrayexpress
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