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TranscriptomicsGene expression profiling in DBA/2J glaucoma
In this study that was specifically designed to identify early stages of glaucoma in DBA/2J mice, we used genome-wide expression profiling and a series of computational methods. Our methods successfully subdivided eyes with no detectable glaucoma by conventional assays into molecularly defined stage...
ORGANISM(S): Mus musculus 
2011-04-15 | E-GEOD-26299 | biostudies-arrayexpress
ProteomicsExamining differential protein expression in brain and retinal tissue from the Mthfr677C>T mouse model
The Mthfr677C>T variant is associated with Alzheimer's disease and vascular dementia. We created a knockin mouse model containing the variant and have been characterizing brain and retinal health in the mice, with special focus on vascular dysfunction. We have shown similar vascular phenotypes in th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD062631 | Pride
Vascular contributions to cognitive impairment and dementia (vcid) Mouse model characterization Brain Neurovascular dysfunction Retina 
ProteomicsGenetic context modulates aging and degeneration in the murine retina
This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging sig...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD057861 | Pride
Genetic diversity Proteomics Retinal vascular disease Tmt Wsb Retinitis pigmentosa Nzo Aging Retina Diabetic retinopathy Lc-ms/ms 
UnknownQuantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420).
Not available
S-EPMC10066938 | biostudies-literature
TranscriptomicsRedox regulation of auxin and strigolactone signaling in the control of Arabidopsis thaliana root growth
Reduced glutathione (GSH) is required for cell cycle initiation and auxin-regulated root meristem development. Transcriptome profiling of the roots and shoots of the root meristemless 1 (rml1) mutant, which has about 3% of the wild type GSH, revealed a divergent auxin and strigolactone response link...
ORGANISM(S): Arabidopsis thaliana 
2013-01-10 | E-GEOD-36893 | biostudies-arrayexpress
UnknownAssociations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
Not available
S-EPMC6734940 | biostudies-literature
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