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The Mthfr677C>T variant is associated with Alzheimer's disease and vascular dementia. We created a knockin mouse model containing the variant and have been characterizing brain and retinal health in the mice, with special focus on vascular dysfunction. We have shown similar vascular phenotypes in th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD062631 | Pride
This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging sig...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD057861 | Pride
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