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ProteomicsHuman Treg LC-MSMS - Foxp3 drives oxidative phosphorylation and protection from lipotoxicity
Regulatory T cells (Treg) have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significa...
ORGANISM(S): Homo sapiens (Human) 
2017-02-15 | PXD001906 | Pride
Human t cell treg foxp3 lc-msms 
ProteomicsFoxp3 positive and negative cell comparison
Regulatory T cells have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significant incr...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD001789 | Pride
Mouse t cells 
TranscriptomicsFoxp3 expression is required for the induction of therapeutic tissue tolerance
CD4+Foxp3+ regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGFB dependent manner. Foxp3+ Treg are also required to achieve tolerance to transplanted tissues when induced...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39529 | biostudies-arrayexpress
TranscriptomicsTolerant and rejecting T cell microarray
anti-CD4, CD8 and CD40L treated versus control murine CD4+ T cells from micegrafted with hESC derived xenografts. Human embryonic stem cells (ESCs), by virtue of their capability to self-renew and differentiate into almost all body cell types, represent the first type of pluripotent stem cells (PSCs...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61867 | biostudies-arrayexpress
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Not available
S-EPMC10163929 | biostudies-literature
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