Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

ABSTRACT: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 × 10^-10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (OR_max = 46.5, p = 1.74 × 10^-15). Association signals for the X-chromosomal gene TLR7 were also detecte

SUBMITTER: Boos J 

PROVIDER: S-EPMC11320601 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature