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GenomicsThe Dynamic Architecture of Hox Gene Clusters
The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architectures remained to be assessed in vivo. Using ...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-31570 | biostudies-arrayexpress
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mamm...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33130 | biostudies-arrayexpress
TranscriptomicsExpression data from the reproductive tracts of WT, Hoxa9,10,11, and Hoxd9,10,11 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions, and their interspersed shared enhancers. In this report, we describe a novel recombineering strategy that was used to introduce simultaneous frameshif...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-41993 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NUP98-NSD1 transformed samples reveals NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. INCOMPLETE DATASET
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10071 | biostudies-arrayexpress
TranscriptomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Infinium HumanMethylation450 Beadchip)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-32362 | biostudies-arrayexpress
GenomicsA single 3D chromatin compartment in amphioxus Hox cluster suggests a stepwise evolutionary origin for vertebrate Hox bimodal regulatory topologies
A single 3D chromatin compartment in amphioxus Hox cluster suggests a stepwise evolutionary origin for vertebrate Hox bimodal regulatory topologies
PRJNA283542 | ENA
GenomicsSynthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [Hi-C]
Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [Hi-C]
PRJNA788890 | ENA
GenomicsSynthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [ChIP-Seq]
Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [ChIP-Seq]
PRJNA788892 | ENA
GenomicsSynthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [RNA-Seq]
Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [RNA-Seq]
PRJNA788894 | ENA
GenomicsSynthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [DNA-Seq]
Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation [DNA-Seq]
PRJNA788891 | ENA
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