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ProteomicsProteome and secretome of HepaRG cells
Primary human hepatocytes, the gold standard for in vitro studies of liver-related functions, suffer from uncertain availability and high variability in cell activity. Over years, a number of alternative hepatic cell lines have lost major liver-like functions, but not HepaRG cells. Therefore, their ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-27 | PXD010304 | Pride
Copy numbers Hpr116 Proteome Functional assays Secretome Surrogate cell system to phh 
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to cosmetic ingredients exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three cosmetics ingredients, 2,7-naphthalenediol (NPT), triclosan (TCS) and butylated hydroxytoluene (BHT), that are suspected to have liver i...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12677 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to drug exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three drugs, acetaminophen (APAP), cyclosporine A (CSA) and valproic acid (VPA), that have a high liability for drug-induced liver injury. To ...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12668 | biostudies-arrayexpress
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