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TranscriptomicsFunctional Connection with Cardiac Tissues Confers Maturation Phenotypes in hPSC-Derived PHOX2B::GFP Expressing Sympathetic Neurons
Neurons derived from human pluripotent stem cells (hPSCs) are a remarkable tool for modeling human neural development and diseases. However, it remains largely unknown whether the hPSC-derived neurons can be functionally coupled with their target tissues in vitro, which is essential for understandin...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-80689 | biostudies-arrayexpress
MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
TranscriptomicsNotch signaling activation in hPSC-derived CNS-like endothelial cells induces differential expression of blood-brain barrier-related genes
Mechanisms guiding the induction of blood-brain barrier (BBB) properties in central nervous system (CNS) endothelial cells during human development are incompletely understood. To explore induction of reduced vesicular endocytosis and transcytosis properties in a human in vitro model of the BBB, we ...
ORGANISM(S): Homo sapiens 
2026-02-17 | E-MTAB-15954 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
TranscriptomicsiPS2-sci-sec dataset on hPSC derived cardiomyocytes at day 23
Proof of principle and testing experiments on  iPS2-sci-seq have been performed on two batches of hPSC-derived cardiomyocytes at day 23. Cells have been treated with Tetracycline throughout differentiation. For this experiment it was used a 2-level of indexing sci-RNAseq protocol (Cao J. et. al, Sci...
ORGANISM(S): Homo sapiens 
2025-10-27 | E-MTAB-14102 | biostudies-arrayexpress
GenomicsGene expression patterns of trisomy 12 hPSC lines
Gene expression patterns of trisomy 12 hPSC lines
PRJNA494430 | ENA
GenomicsRNA sequencing of hPSC-derived cardiac progenitors and endocardium
RNA sequencing of hPSC-derived cardiac progenitors and endocardium
PRJNA427332 | ENA
GenomicsRNA-seq analysis of hPSC-derived brain pericyte-like cells, hPSC-derived neural crest stem cells, and primary human brain pericytes
RNA-seq analysis of hPSC-derived brain pericyte-like cells, hPSC-derived neural crest stem cells, and primary human brain pericytes
PRJNA512529 | ENA
GenomicsA hPSC system for characterizing MUC5B-expressing airway epithelia
A hPSC system for characterizing MUC5B-expressing airway epithelia
PRJNA835444 | ENA
TranscriptomicsscRNA-seq of hPSC-derived human intestinal organoids with endogenous vascular endothelial cells
The development of human pluripotent stem cell (hPSC)- derived small intestinal organoids (HIOs) has led to an improved understanding of human intestinal development and physiology. HIOs generated using directed differentiation lack some cellular populations found in the native organ, including vasc...
ORGANISM(S): Homo sapiens 
2020-12-20 | E-MTAB-9228 | biostudies-arrayexpress
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