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TranscriptomicsEffect of HPV 16 E6, E7 oncoproteins on the expression level of cellular genes
The life cycle of human papillomaviruses (HPV) is strictly linked to the differentiation of their natural host cells. The HPV E6 and E7 oncoproteins can delay the normal differentiation program of keratinocytes, however, the exact mechanisms responsible for this have not yet been identified. The goa...
ORGANISM(S): Homo sapiens 
2014-06-26 | E-GEOD-58841 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequencing and Novel HPV miRNA discovery in HPV cell lines and human tissue samples
Human papillomaviruses (HPV) preferentially infect keratinocytes of mucous membranes or skin and cause numerous benign and malignant lesions at different anatomical locations. A number of DNA viruses encode their own miRNAs as well. To date, no studies have been able to validate viral miRNAs in papi...
ORGANISM(S): Homo sapiens 
2013-08-18 | E-GEOD-42380 | biostudies-arrayexpress
ProteomicsA ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6
The E6 protein of both mucosal high risk human papillomaviruses (HPVs) such as HPV-16, which have been causally associated with malignant tumors, and low risk HPVs such as HPV-11, which cause the development of benign tumors, interacts with the cellular E3 ubiquitin ligase E6AP. This indicates that ...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD020660 | Pride
Tumor virus Tmt E6ap/ube3a Human papillomavirus E3 ubiquitin ligase E6 oncoprotein Oncogene Protein degradation Ubiquitin 
GenomicsSplicing characterization and isoform switch events in human keratinocytes carrying oncogenes from high-risk HPV-16 and low-risk HPV-84
Splicing characterization and isoform switch events in human keratinocytes carrying oncogenes from high-risk HPV-16 and low-risk HPV-84
PRJNA948450 | ENA
GenomicsA Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
PRJNA673943 | ENA
GenomicsA Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
PRJNA673944 | ENA
ClinicalT Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with cancer that involves taking white blood cells from the patient, growing them in the laboratory in large numbers, genetically modifying these specific cells with a type of v...
2177506 | ecrin-mdr-crc
UnknownHPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation.
Not available
S-EPMC3400011 | biostudies-literature
GenomicsmicroRNA expression profiling in HPV-16/HIV associated Cervical Cancer
Identifying the differentially expressed miRNAs in Cervical cancer patients infected with only one virus i.e. either HIV or HPV-16 and patients infected with both viruses HIV and HPV-16 with respect to their controls which is the healthy population not infected by either HIV or any HPV The miRNA arr...
ORGANISM(S): synthetic construct Homo sapiens 
2018-08-01 | GSE81137 | GEO
UnknownChimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16.
Not available
S-EPMC165259 | biostudies-literature
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