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ProteomicsIdentification of small molecule activators of the ubiquitin ligase E6AP/UBE3A and Angelman syndrome-derived E6AP/UBE3A variants
Genetic aberrations of the UBE3A gene encoding the E3 ubiquitin ligase E6AP underlie the development of Angelman syndrome (AS). Approximately 10 percent of AS individuals harbor UBE3A genes with point mutations, frequently resulting in the expression of full-length E6AP variants with defective E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD020602 | Pride
Ube3a Angelman syndrome Crosslinking coupled to mass spectrometry E6ap Small molecule activator Fluorescence polarization Xl-ms Ubiquitin ligase High-throughput screen 
ProteomicsCobalamins function as allosteric activators of an Angelman syndrome-associated UBE3A/E6AP variant
Genetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD048963 | Pride
Lip-ms Small molecule activators Qxl-ms Structural proteomics Ube3a Angelman syndrome 
UnknownAssociation of E6AP (UBE3A) with human papillomavirus type 11 E6 protein.
Not available
S-EPMC1892534 | biostudies-literature
UnknownThe HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders.
Not available
S-EPMC7464832 | biostudies-literature
UnknownRole of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc.
Not available
S-EPMC3670309 | biostudies-literature
UnknownAngelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome.
Not available
S-EPMC4669770 | biostudies-literature
UnknownE6AP/UBE3A catalyzes encephalomyocarditis virus 3C protease polyubiquitylation and promotes its concentration reduction in virus-infected cells.
Not available
S-EPMC5675005 | biostudies-literature
ProteomicsStructural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts ...
ORGANISM(S): Human papillomavirus type 16 Homo sapiens (Human) 
2018-10-23 | PXD010002 | Pride
Xl-ms E6 oncoprotein Ubiquitin E6ap/ube3a P53 Papillomavirus 
UnknownMultiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.
Not available
S-EPMC6999913 | biostudies-literature
ProteomicsProteomic Profiling of Potential E6AP Substrates via Ubiquitin-based Photo-Crosslinking Assisted Affinity Enrichment
E6AP/UBE3A, the founding member of HECT-type (Homologous to E6AP C-terminus) E3 ligases, is implicated in human papillomaviruses (HPV)-mediated cervical cancer and neurodevelopmental disorders like Angelman and Dup15q syndromes. To elucidate the function of E3 ligases, knowledge about their substrat...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD055649 | Pride
Photoaffinity labelling Proteomics Substrate identification Ubiquitination E6ap/ube3a 
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