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TranscriptomicsDepletion of HPV16 oncogenes induces autophagy and senescence in a cervical carcinogenesis model, irrespective of viral physical state
We utilised our in vitro model of cervical neoplastic progression, W12, to investigate the effect of HPV16 viral oncogene depletion on well-defined integrant- and episome- associated series. To target HPV16 viral oncogenes we used our previously published E7-targeting siRNA sequence that caused subs...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-MTAB-1331 | biostudies-arrayexpress
GenomicsHuman Papillomavirus strain:HPV16
Human Papillomavirus strain:HPV16 Genome sequencing
PRJNA240947 | ENA
ProteomicsEffects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells
Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have not been clinically successful to date. One reason may be the hypoxic microenvironment present in most tumors, including cervical cancer. Hypoxia dysregulates the levels of human leukocyte antigen ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD032217 | Pride
Antigen presentation machinery (apm) Cytotoxic cd8+ t cells Hpv16 
GenomicsTargeted capture DNA-seq for HPV16-human breakpoint junctions in HPV16 infected W12 cervical cell lines
HPV integrated site capture (HISC) protocol used to detect HPV16 integration breakpoints in the genomes of W12 cell lines. Biotinylated HPV16-specific RNA baits were used to capture HPV16-human breakpoint junctions in genomic DNA.
ORGANISM(S): Homo sapiens 
2021-06-18 | E-MTAB-10154 | biostudies-arrayexpress
TranscriptomicsIdentification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells.
The W12 cell lineage recapitulates the early events in HPV-driven cervical cancer pathogenesis (which is impossible to investigate using clinical samples) and we are interested in characterising the host transcriptional events that occur at those early stages. Previous work in these cells has identi...
ORGANISM(S): Homo sapiens 
2016-11-30 | E-MTAB-4409 | biostudies-arrayexpress
ProteomicsImpact of HPV16 E6 and E7 oncogenes together with Chlamydia trachomatis infection on proteome changes in immortalized oral keratinocytes
Certain types of Human papilloma viruses (HPV) are the etiological agents for cervical cancer. However, not all infections of high-risk HPVs will finally lead to cancer since most HPV infections are cleared without any consequences. Chlamydia trachomatis is the most prevalent sexual transmitted bact...
ORGANISM(S): Human papillomavirus type 16 Chlamydia trachomatis Homo sapiens (Human) 
2019-03-18 | PXD012186 | Pride
Cervical cancer Human papillomavirus Chlamydia trachomatis 
TranscriptomicsMassively parallel single-cell RNA-sequencing of K14E7 transgenic and wildtype C57BL/6 mice
We report scRNA-seq data captured from 9,410 cells obtained from the skin of K14E7 transgenic and wildtype C57/BL6 mice. The K14E7 mouse model harbors the HPV16 E7 oncogene driven from a Keratin 14 promoter for keratinocyte-specific expression. We used scRNA-seq to detect and measure E7 transcriptio...
ORGANISM(S): Mus musculus 
2018-07-09 | E-MTAB-6429 | biostudies-arrayexpress
TranscriptomicsTransfection of HaCaT cells with HPV11 HPV16 or HPV45 genome
We investigated the early stage of HPV infections by global expression profiling in a cell model, in which cells from the human keratinocyte cell line, HaCaT, were transfected with HPV11, HPV16 or HPV45 genomes ( methods used for transfection are described in PubMed ID: 21078297)
ORGANISM(S): Homo sapiens 
2012-07-01 | E-MTAB-1160 | biostudies-arrayexpress
GenomicsTargeted capture DNA-seq for HPV16-human breakpoint junctions in HPV16 infected W12 cervical cell lines
Targeted capture DNA-seq for HPV16-human breakpoint junctions in HPV16 infected W12 cervical cell lines
PRJEB43329 | ENA
GenomicsIdentification of HPV16 in Anhui,China
Identification of HPV16 in Anhui,China
PRJEB1792 | ENA
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