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MetabolomicsInvestigating the Impact of Acinetobacter lwoffii-ECT1/E6E7 Co-culture Metabolites on Cervical Cell Proliferation and Apoptosis via Untargeted Metabolomics.

This study employed untargeted metabolomics detection combined with bioinformatics analysis to investigate the metabolites from the co-culture of Acinetobacter lwoffiiand cervical precancerous cells ECT1/E6E7. A. lwoffiiwas co-cultured with ECT1/E6E7 cells at an MOI of 100. The culture supernatan...

2025-12-17 | MTBLS13526 | MetaboLights
TranscriptomicsMicroRNA expression profile in human foreskin keratinocytes (HFKs) transduced with retroviral vectors carrying E6 and E7 genes of either HPV6 or HPV16 and with the LXSN empty vector
Cervical cancer is a leading cause of cancer-related death in women worldwide. Nearly all cases of cervical cancer are attributed to infection with human papillomavirus (HPV), mainly high-risk type HPV16 and HPV18. Two viral genes, E6 and E7, play an important role in viral life cycle, since they de...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6360 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human foreskin keratinocytes expressing E6 or E7 compared to normal keratinocytes reveals HPV16 E7 induces EMT
Gene expression data from human foreskin keratinocytes expressing E6 or E7 compared to normal keratinocytes.
ORGANISM(S): Homo sapiens 
2009-06-04 | E-MTAB-114 | biostudies-arrayexpress
TranscriptomicsIdentification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells.
The W12 cell lineage recapitulates the early events in HPV-driven cervical cancer pathogenesis (which is impossible to investigate using clinical samples) and we are interested in characterising the host transcriptional events that occur at those early stages. Previous work in these cells has identi...
ORGANISM(S): Homo sapiens 
2016-11-30 | E-MTAB-4409 | biostudies-arrayexpress
TranscriptomicsDepletion of HPV16 oncogenes induces autophagy and senescence in a cervical carcinogenesis model, irrespective of viral physical state
We utilised our in vitro model of cervical neoplastic progression, W12, to investigate the effect of HPV16 viral oncogene depletion on well-defined integrant- and episome- associated series. To target HPV16 viral oncogenes we used our previously published E7-targeting siRNA sequence that caused subs...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-MTAB-1331 | biostudies-arrayexpress
ProteomicsProteomic Analysis of the E6 Interactome in Response to Anisomelic Acid Treatment
Human papillomavirus (HPV) is a well-known cause of cervical cancer, with the viral oncoprotein E6 playing a key role in carcinogenesis. We previously showed that anisomelic acid treatment reduces E6 protein levels in HPV-positive cancer cells. In this study, we used mass spectrometry-based proteomi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD065382 | Pride
Lc-ms/ms Anisomelic acid Normal oral keratinocytes Hpv16 e6 
ProteomicsImpact of HPV16 E6 and E7 oncogenes together with Chlamydia trachomatis infection on proteome changes in immortalized oral keratinocytes
Certain types of Human papilloma viruses (HPV) are the etiological agents for cervical cancer. However, not all infections of high-risk HPVs will finally lead to cancer since most HPV infections are cleared without any consequences. Chlamydia trachomatis is the most prevalent sexual transmitted bact...
ORGANISM(S): Human papillomavirus type 16 Chlamydia trachomatis Homo sapiens (Human) 
2019-03-18 | PXD012186 | Pride
Cervical cancer Human papillomavirus Chlamydia trachomatis 
ProteomicsEffects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells
Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have not been clinically successful to date. One reason may be the hypoxic microenvironment present in most tumors, including cervical cancer. Hypoxia dysregulates the levels of human leukocyte antigen ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD032217 | Pride
Antigen presentation machinery (apm) Cytotoxic cd8+ t cells Hpv16 
TranscriptomicsExpression signatures and cytogenetic aberrations in HPV16 E6, E7 and E6/E7-positive immortalized human epithelial cells
Identification of genetic/cytogenetic alterations and differentially expressed cellular genes in HPV16 E6, E7 and E6/E7 positive human foreskin keratinocytes Keywords: ordered We used microarrays to identify differentially expressed genes in human foreskin keratinocytes (HFK) transfected with retro...
ORGANISM(S): Homo sapiens 
2013-11-27 | E-GEOD-14051 | biostudies-arrayexpress
TranscriptomicsHuman HPV16 positive CaSki cells: Control vs. virus oncogene e6/e7 silenced
The infection with high-risk human papillomavirus is aetiologically linked to cervical cancer, the role of miRNAs regulated by virus oncogene in cancer progression remain largely unknown. Here, we screened the differentially expressed miRNAs with miRNA array between virus oncogene e6/e7 silenced and...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-68153 | biostudies-arrayexpress
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