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MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
MetabolomicsDiverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood
During human fasting, metabolic markers, including butyrates, carnitines, and branched-chain amino acids, are upregulated for energy substitution through gluconeogenesis and use of stored lipids. We performed non-targeted, accurate semiquantitative metabolomic analysis of human whole blood, plasma, ...
2019-09-11 | MTBLS549 | MetaboLights
MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
MetabolomicsUnique metabolomic profile of skeletal muscle in chronic limb threatening ischemia (HR-MAS study)
Not available
ORGANISM(S): Homo sapiens 
ST001617 | MetabolomicsWorkbench
MetabolomicsOptimization of Imputation Strategies for High-Resolution Gas Chromatography-Mass Spectrometry (HR GC-MS) Metabolomics Data
Not available
ORGANISM(S): Papio hamadryas 
ST002132 | MetabolomicsWorkbench
Metabolomics1H HR-MAS NMR based metabolomics of cancer cells responding to two different doses of the diruthenium trithiolato complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1)
The trithiolato bridged diruthenium complex DiRu-1 [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ is highly cytotoxic against various cancer cell lines, but its exact mode of action remained unknown. The present 1H HR-MAS NMR based metabolomic study performed on the ovarian cancer cell lines A2780, its cisPt re...
2019-07-04 | MTBLS1014 | MetaboLights
GenomicsScleroderma citrinum strain:hr.
Scleroderma citrinum hr. Transcriptome - Sc hr. RNA
PRJNA710968 | ENA
GenomicsZavarzinia compransoris strain:HR-AS
Zavarzinia compransoris strain:HR-AS Genome sequencing
PRJNA434614 | ENA
TranscriptomicsNear naked hairless, Hr(n), and Hr(Rh-R) mice
This SuperSeries is composed of the following subset Series: GSE4052: Near Naked Hairless mouse skin array GSE4053: ORNL 5wk Hr(n)/+ mice skin array GSE4055: ORNL Hr(Rh-R) mouse cutaneous array Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4059 | biostudies-arrayexpress
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