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Bulk RNA sequencing of optic nerves from wild-type and oligodendrocyte HRasG12V mutant mice
Epidermal basal cell-specific in vivo ribosome profiling to describe the translation landscape of HrasG12V and Eif2b5
eIF2B5 is necessary for HrasG12V hyperplastic growth. Ribosome profiling was used to describe HrasG12V and WT dependence on eIF2B5-mediated translation.
ORGANISM(S): Mus musculus 
2020-06-10 | GSE126660 | GEO
Learning issues in the complex wheel test were observed two weeks after inducing the Costello syndrome-causing mutation HRasG12V in adult mouse oligodencrocytes. Bulk RNA sequencing of optic nerves (rich in oligodendrocytes) was performed to identify transcriptional changes after induction of HRasG1...
ORGANISM(S): Mus musculus 
2026-09-11 | GSE346268 | GEO
Effects of zinc ions and HrasG12V-activated signaling on gene expression of rat embryonic fibroblasts maintained in serum-free media
Gene expression profiling of E1A HrasG12V mouse embryonic fibroblasts grown under physiological (5%) oxygen conditions, with wild-type p53 or p53 null
To investigate how pleiotropic the impact of p53 loss is on cellular function, generated isogenic, polyclonal wild-type (sgNTC) and p53-null (sgp53) E1A;HrasG12V mouse embryonic fibroblast cell lines using CRISPR/Cas9. Here we show gene expression analysis on p53 wild-type (sgNTC) and p53null (sgp53...
ORGANISM(S): Mus musculus 
2020-08-07 | GSE136355 | GEO
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