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ProteomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
Impaired protein homeostasis promotes age-associated tissue dysregulation, presenting a need for therapeutic approaches that can restore proteome integrity. The heat shock factor HSF-1 is the master transcriptional regulator of proteostasis and regulates the expression of heat shock proteins (HSPs),...
ORGANISM(S): Caenorhabditis elegans 
2024-10-17 | PXD044595 | Pride
Hsf-1  aging  proteomics 
GenomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
HSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
PRJNA1008701 | ENA
GenomicsEffects of ash-2, hsf-1, or ash-2 + hsf-1 RNAi on gene expression in Day 1 adult Q40::YFP C. elegans
Effects of ash-2, hsf-1, or ash-2 + hsf-1 RNAi on gene expression in Day 1 adult Q40::YFP C. elegans
PRJNA946282 | ENA
GenomicsUsing Auxin-inducible-degradation System to Interrogate Tissue-specific Transcriptional Programs of HSF-1 in Lifespan Assurance [HSF-1 transcriptome in the soma]
Using Auxin-inducible-degradation System to Interrogate Tissue-specific Transcriptional Programs of HSF-1 in Lifespan Assurance [HSF-1 transcriptome in the soma]
PRJNA838551 | ENA
GenomicsLoss of hsf-1 initiates intracellular lipid surveillance
Loss of hsf-1 initiates intracellular lipid surveillance
PRJNA822383 | ENA
TranscriptomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
In this experiment, we aimed to determine the gene expression changes associated with loss of UBQL-1 in wildtype and in worms overexpressing HSF-1 (hsf-1 OE).
ORGANISM(S): Caenorhabditis elegans 
2023-09-01 | GSE241558 | GEO
GenomicsComparison of gene expression in the long-lived hsb-1 mutant and hsf-1 overexpression C. elegans strains
Comparison of gene expression in the long-lived hsb-1 mutant and hsf-1 overexpression C. elegans strains
PRJNA491191 | ENA
TranscriptomicsUsing Auxin-inducible-degradation System to Interrogate Tissue-specific Transcriptional Programs of HSF-1 in Lifespan Assurance [HSF-1 transcriptome in the soma]
To determine the transcriptional program of HSF-1 in lifespan assurance in C. elegans, we coupled HSF-1 depletion specifically from the soma by auxin-inducible degron (AID) with RNA-seq analyses in whole animals. Depletion of HSF-1 from the soma was performed by transferring worms that express the E...
ORGANISM(S): Caenorhabditis elegans 
2022-05-19 | GSE203087 | GEO
TranscriptomicsRNA-seq analysis of hsf-1 mutant in C. elegans larval development
To understand the function and regulation of the C. elegans heat shock factor (HSF-1) in larval development, we have used ChIP-seq to analyze the occupancy of HSF1 and RNA Pol II in L2 larvae and young adult (YA) animals grown at 20°C or upon heat shock at 34°C for 30 min. In addition, we have used ...
ORGANISM(S): Caenorhabditis elegans 
2016-10-12 | GSE81522 | GEO
ProteomicsMS identification of HSF-1's interacting proteins
Identification of C. elegans HSF-1's interacting proteins under physiological conditions by mass spectrometry
ORGANISM(S): Caenorhabditis Elegans 
2025-05-29 | PXD064433 |
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