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TranscriptomicsChitosan-affected gene expression profiles in brain and stomach
Chitosan has been widely used in food industry as a weight-loss aid and a cholesterol-lowering agent. Previous studies have shown that chitosan affects metabolic responses and contributes to anti-diabetic, hypocholestermic, and blood glucose-lowering effects; however, the in vivo targeting sites and...
ORGANISM(S): Mus musculus 
2014-10-29 | E-GEOD-33565 | biostudies-arrayexpress
TranscriptomicsElectroacupuncture Improves Trinitrobenzene Sulphonic Acid-Induced Colitis, Evaluated by Transcriptomic Study
Inflammatory bowel disease is a chronic colonic inflammation that displays symptoms like diarrhea and weight loss. Acupuncture has been widely accepted by Western countries for the treatment of pain. In this study, we analyzed the efficacy and mechanism of electroacupuncture (EA) on trinitrobenzene ...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-57771 | biostudies-arrayexpress
ProteomicsClove (Syzygium aromaticum) and its bioactive constituent eugenol alleviate psoriatic inflammation by modulating the IL-36/IL-17A axis: A proteomic and mechanistic study
An imiquimod (IMQ)-induced psoriasis-like mouse model was employed to assess the therapeutic effects of orally administered clove extract and eugenol. iTRAQ-based LC–MS/MS proteomics were performed to identify molecular alterations, followed by bioinformatics analyses.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD077433 | Pride
Syzygium aromaticum  eugenol  psoriasis  interleukin-17a  interleukin-36  proteomics 
TranscriptomicsA novel insulin receptor-binding protein enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway
In this study, a novel IR-binding protein (IRBP) from Momordica charantia, named as mcIRBP, was identified by analyzing the physical and functional interactions between mcIRBP and IR. The hypoglycemic effect and mechanism of mcIRBP were further evaluated in normal and streptozotocin-induced diabetic...
ORGANISM(S): Mus musculus 
2016-06-25 | E-GEOD-48274 | biostudies-arrayexpress
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