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ProteomicsEP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis remains largely unknown. Here, we report that E1A binding protein P300 (EP300) acetyltransfera...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039998 | Pride
Human Cell Ip-ms Pdac 
UnknownNew progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19.
Not available
S-EPMC10232979 | biostudies-literature
TranscriptomicsNew compounds triggering endoplasmic reticulum stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
We discovered and developed a new series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all tested melanoma cells including those isolated from patients and those that developed resistance to BRAF inhibitors. Our molecule dis...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79071 | biostudies-arrayexpress
UnknownEvaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19.
Not available
S-EPMC7975696 | biostudies-literature
UnknownInteraction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain.
Not available
S-EPMC7385938 | biostudies-literature
UnknownIntranasal Administration of GRP78 Protein (HSPA5) Confers Neuroprotection in a Lactacystin-Induced Rat Model of Parkinson's Disease.
Not available
S-EPMC11011682 | biostudies-literature
UnknownEP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer.
Not available
S-EPMC10495396 | biostudies-literature
UnknownEbola virus glycoprotein GP1-host cell-surface HSPA5 binding site prediction.
Not available
S-EPMC7154572 | biostudies-literature
TranscriptomicsGRP78 regulates ER homeostasis and distal epithelial cell survival during lung development
Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, has been linked to endoplasmic reticulum (ER) stress. To investigate a causal role for ER stress in BPD pathogenesis, we generated mice (cGrp78f/f) with lung epithelial cell-specific knockout (KO) of Grp78, a gene encoding the ...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-70208 | biostudies-arrayexpress
UnknownHeat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Not available
S-EPMC9114370 | biostudies-literature
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