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MetabolomicsN6-methyladenosine–modified circSLTM inhibits gastric cancer cell proliferation and promotes ferroptosis via interaction with HSPA8

Circular RNAs (circRNAs) are dysregulated in cancers, with N6-methyladenosine (m⁶A)-modified species acting as key regulators of ferroptosis via iron metabolism and lipid peroxidation. This study examines the role of circSLTM (circ-0000605) in gastric cancer (GC). Clinical analyses of GEO data an...

2026-01-16 | MTBLS13702 | MetaboLights
GenomicsRNA-seq of HSPA8 knockdown in MDA-MB-468 cells
RNA-seq of HSPA8 knockdown in MDA-MB-468 cells
PRJEB102282 | ENA
TranscriptomicsRNA-seq of HSPA8 knockdown in MDA-MB-468 cells
We used three siRNAs to silence HSPA8 in MDA-MB-468 cells, and then used RNA-seq to compare HSPA8 knockdown cells with the controls.
ORGANISM(S): Homo sapiens 
2025-11-13 | E-MTAB-16073 | biostudies-arrayexpress
GenomicsHSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation
PRJNA1195349 | ENA
GenomicsUCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8
UCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8
PRJNA993683 | ENA
TranscriptomicsHSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation
Lipid accumulation in the renal tubules is a major determinant of diabetic kidney disease (DKD), and activation of SREBPs plays a central role in this process. Our study aimed to explore whether HSPA8, a molecular chaperone, is the master regulator of INSIG/SREBPs function in DKD. Here, we showed th...
ORGANISM(S): Mus musculus 
2024-12-12 | GSE283754 | GEO
TranscriptomicsUCHL1 Maintains Microenvironmental Homeostasis of Male Germline Stem Cells by Antagonizing HSPA8
To illustrate the mechanism of UCHL1 and HSPA8 affects SSCs in the testis, mGSCs-I-SB cells were used to study in vitro, we down-regulated UCHL1 and HSPA8 using shRNA in mGSCs-I-SB cells. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different cells
ORGANISM(S): Capra hircus 
2026-07-01 | GSE237083 | GEO
UnknownHigh HSPA8 expression predicts adverse outcomes of acute myeloid leukemia.
Not available
S-EPMC8086305 | biostudies-literature
UnknownHSPA8 regulates anti-bacterial autophagy through liquid-liquid phase separation.
Not available
S-EPMC10472862 | biostudies-literature
ProteomicsThe heat shock protein family A (HSPA8) acts as a surface receptor of alveolar macrophages specific for recognition and phagocytosis of Lichtheimia corymbifera spores
Mucormycosis is a life-threatening disease especially in immunocompromised patients that was caused my mucoralean fungi. The rate of mortality is tremendously increased in the last decades due to the lack of appropriate diagnostic tools, insufficient knowledge about the immune response toward the...
ORGANISM(S): Lichtheimia corymbifera JMRC:FSU:9682 Mus musculus (Mouse) 
2020-07-17 | PXD014197 | Pride
Hspa8 Mass spectrometry Alveolar macrophages Surface receptor Lichtheimia corymbifera Biotinylation 
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