In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli
This dataset comprises a bulk transcriptomic profile of bone marrow flush from tibia of C57BL/6N mice. Differential gene expression analysis was performed comparing old (67-71-week-old; n = 3 males and 3 females) versus young (8-week-old; n = 3 males and 3 females) mice. Data was generated separat...
Model of the Complement System
This is the continuous deterministic (ODE) model of the complement system described in the article:
Computational and Experimental Study of the Regulatory Mechanisms of the Complement System.
Liu B, Zhang J, T...