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TranscriptomicsIdentification of RVE8 target genes
The goal of this study is to identify the targets of RVE8, a MYB-like transcription factor involved in the circadian clock in Arabidopsis. Analysis of 7 days old rve8-1 RVE8::RVE8:GR and rve8-1 seedlings treated with dexamethasone or mock identified genes responsive to RVE8 induction.The RVE8 up-reg...
ORGANISM(S): Arabidopsis thaliana 
2013-04-15 | E-GEOD-38879 | biostudies-arrayexpress
UnknownLoss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Not available
S-EPMC6355067 | biostudies-literature
TranscriptomicsProstate Cancer Gene Expression Changes after Treatment with Neoadjuvant Dutasteride
To identify molecular changes underlying the chemopreventive or tumor promoting effects of SRD5A inhibition, we profiled gene expression changes in benign prostate epithelium from patients with PCa treated with dutasteride, a dual SRD5A inhibitor. Subjects were aged 45-80 years with clinically local...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9972 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsExpression data comparing high serum-binding subline of C10F4 (named C10F4-S) with its parental line, C10F4
Comparison of high serum-binding subline of C10F4 (C10F4-S) with its parental line C10F4 cells and normal mouse lung.
ORGANISM(S): Mus musculus 
2020-02-07 | E-MTAB-6936 | biostudies-arrayexpress
TranscriptomicsStrand-specific transcriptomes of Saccharomyces cerevisiae and Saccharomyces paradoxus
Background: Recent studies have demonstrated that antisense transcription is pervasive in budding yeasts and is conserved between Saccharomyces cerevisiae and S. paradoxus. While studies have examined antisense transcripts of S. cerevisiae for inverse transcription in stationary phase and stress con...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-09 | E-GEOD-58319 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes with Neoadjuvant Hormone Therapy
Men with clinically localized prostate cancer were treated with 0 to 9 months of neoadjuvant hormone suppression prior to prostatectomy. Keywords: microarray, hormone, 9 men with prostate cancer were assigned to neoadjuvant hormone suppression therapy for 3-6, 6, or 0 months.
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9983 | biostudies-arrayexpress
GenomicsGenome-wide mapping of HIST1H2ac binding sites in MCF-7 cells
Previously, we have shown that HIST1H2ac is overexpressed in MCF-7 breast cancer cell line. It acts as a master regulator of estrogen receptor alpha-dependent gene expression in ER+ breast cancer cells. In the present study, we investigate the genome-wide protein DNA-binding events of HIST1H2ac prot...
ORGANISM(S): Homo sapiens 
2016-05-19 | E-MTAB-3160 | biostudies-arrayexpress
TranscriptomicsThe invasion promoter Slug is a critical cell cycle regulator
Background: The well-characterized function of the transcriptional repressor, Slug, is to promote EMT and tumor invasion/metastasis by down-regulating E-cadherin expression. In this study, we investigated the significance of Slug during the S phase. Method: Slug mRNA expression was isolated from thy...
ORGANISM(S): Homo sapiens 
2012-02-09 | E-GEOD-35617 | biostudies-arrayexpress
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