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ProteomicsAnalysis of the fragments from hTau degraded by proteasome 20s using mass spectrometry
We found two stable intermediates in the interaction of human Tau and proteasome 20s. The aim of this study is to determine the cleavage sites on hTau during this process.
ORGANISM(S): Escherichia coli 
2020-04-22 | PXD015349 | Pride
Htau Mass spectrometry 
ProteomicsStructural mapping of the surfaces of fibrillar 1N3R and 1N4R human tau
The structural characterization of pathogenic tau filaments that accumulate in tauopathies, including Alzheimer disease, is key for understanding their pathogenic function and identify the structural determinants of distinct tau filaments involved in distinct tauopathies. Fibrillar tau surfaces play...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027403 | Pride
Structural proteomics  proteolysis  chemical surface modification  nhs-biotin  nanolc-msms Tau fibrils 
ProteomicsAnalysis of human tau and age dependent changes in the synaptic and non-synaptic mitochondrial proteomes of the htau model of tauopathy
We investigated the effects of human tau on subcellular populations of the brain mitochondrial proteome in vivo using transgenic htau mice at ages preceding (5 months) and coinciding with (8 months) onset of tauopathy.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD030950 | Pride
Mitochondria Alzheimer's Synaptic Human Tau 
Genomics
hTauKI hTauKI hTau-KIS305N_3 sequencing
PRJNA1152251 | ENA
TranscriptomicsWhole genome gene expression analysis of a genomic mouse model of tauopathy
The goal of this study was to assess the number and types of differentially expressed genes in a transgenic (genomic) mouse model of tau pathology. Notably, we crossed previously described genomic mouse line called ‘8c’ that expresses all isoforms of human tau protein (Duff et al., Neurobiology ...
ORGANISM(S): Mus musculus 
2017-03-15 | E-MTAB-5078 | biostudies-arrayexpress
UnknownP301S-hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau-induced synaptic toxicities.
Not available
S-EPMC9345400 | biostudies-literature
UnknownNAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.
Not available
S-EPMC5769520 | biostudies-literature
UnknownDysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model.
Not available
S-EPMC9223516 | biostudies-literature
UnknownExpression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.
Not available
S-EPMC5478664 | biostudies-literature
UnknownIncreasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation.
Not available
S-EPMC7066213 | biostudies-literature
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