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no omics definedTranscription profiling of human acute myeloid leukemia cells to identify compounds inducing the differentiation of acute myeloid leukemia cells
We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute ...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-995 | biostudies-arrayexpress
TranscriptomicsMethod Study
High-throughput sequencing (HTS) of antibody amplicon libraries has become a powerful method in the emerging field of systems immunology. However, numerous sources of bias in HTS workflows may affect antibody repertoire data. A crucial step in antibody amplicon library preparation is the addition of...
ORGANISM(S): Mus musculus 
2014-02-20 | E-MTAB-2226 | biostudies-arrayexpress
ProteomicsComparative analysis of maca (Lepidium meyenii) proteome profiles reveals insights into response mechanisms of herbal plants to high-temperature stress
High-temperature stress (HTS) is one of the main environmental stresses that limit plant growth and crop production in agricultural systems. Maca (Lepidium meyenii) is an important high-altitude herbaceous plant adapted to a wide range of environmental stimuli such as cold, strong wind and UV-B expo...
ORGANISM(S): Lepidium meyenii 
2020-08-25 | PXD021042 | Pride
High-temperature stress Stress response Tandem mass tag Molecular mechanism Maca 
TranscriptomicsGene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences
Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a singl...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53230 | biostudies-arrayexpress
TranscriptomicsBias in ligation-based small RNA sequencing library construction is determined by adaptor and RNA structure
High-throughput sequencing (HTS) has become a powerful tool for the detection of and sequence characterization of microRNAs (miRNA) and other small RNAs (sRNA). Unfortunately, the use of HTS data to determine the relative quantity of different miRNAs in a sample has been shown to be inconsistent wi...
ORGANISM(S): synthetic construct 
2015-05-15 | E-GEOD-67053 | biostudies-arrayexpress
TranscriptomicsTriticum aestivum strain:cultivar Transcriptome or Gene expression
The pistillody mutant wheat (Triticum aestivum L.) plant HTS-1 exhibits homeotic transformation of stamens into pistils or pistil-like structures. Unlike common wheat varieties, HTS-1 produces three to six pistils per floret, potentially increasing the yield. Thus, HTS-1 is highly valuable in the st...
ORGANISM(S): Triticum aestivum 
2014-03-14 | E-MTAB-4469 | biostudies-arrayexpress
GenomicsBarcodes from HTS data
HTS data as a source of diatom barcode sequences
PRJEB27890 | ENA
GenomicsTranscriptome analysis of Human Trophoblast Stem cell (HTS) and TEAD4 knock down HTS cells by next generation sequencing
Transcriptome analysis of Human Trophoblast Stem cell (HTS) and TEAD4 knock down HTS cells by next generation sequencing
PRJNA604985 | ENA
GenomicsBarcode sequences from HTS data
HTS data as a source of diatom barcode sequences
PRJEB27918 | ENA
TranscriptomicsTranscriptome analysis of Human Trophoblast Stem cell (HTS) and TEAD4 knock down HTS cells by next generation sequencing
mRNA profiles of control Human Trophoblast Stem cell (HTS) and TEAD4 knock down HTS cells were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000 platform. TEAD4 Knock down in HTS cells were confirmed by RT-PCR analysis and immuno staining.
ORGANISM(S): Homo sapiens 
2020-05-29 | GSE144809 | GEO
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