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TranscriptomicsSex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life ...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-26025 | biostudies-arrayexpress
TranscriptomicsPrenatal stress-induced programming of genome-wide promoter DNA methylation in 5-Htt deficient mice
The serotonin transporter (5-HTT) gene-linked polymorphic region has been suggested to play a modulatory role in mediating the effects of early-life stress on psychopathology rendering carriers of the low-expression short (s)-allele more vulnerable to environmental adversity in later life. Here we a...
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-51634 | biostudies-arrayexpress
TranscriptomicsContinuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.
In Huntington’s disease (HD), expanded HTT CAG repeat length correlates strongly with age at motor onset, indicating that it determines the rate of the disease process leading to diagnostic clinical manifestations. Similarly, in normal individuals, HTT CAG repeat length is correlated with biochemica...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-34721 | biostudies-arrayexpress
ProteomicsAscorbate peroxidase (APEX2) -mediated proximity-based proteomics for HTT protein interactions
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059663 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
ProteomicsHuntingtin interactome in human striatal neurons derived from iPSCs upon the induction of double strand break (DSB) DNA damage response
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059660 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
ProteomicsHTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration
We have developed a web-based platform for HTT PPI visualization, exploration, and multi-omic integration called HTT-OMNI. We demonstrate the utility of this platform not only for exploring and filtering existing huntingtin (HTT) PPIs, but also for investigating user-generated omics datasets. For ex...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD034158 | Pride
Computational tool Huntington's disease Ip-ms Protein interactions 
TranscriptomicsTranscription profiling of rat Htt14A2.5 (PC12) cells expressing truncated Htt exon 1-EGFP fusion protein
Htt14A2.5 is a clonal rat pheochromocytoma (PC12) cell line, that expresses a truncated form of expanded repeat Htt exon 1 protein fused at the C-terminus to enhanced green fluorescent protein (EGFP). For total RNA preparation, ~3 x 105 cells were plated on 150 mm plates and the following day eithe...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2602 | biostudies-arrayexpress
GenomicsChIP-seq of HTT protein in mouse cortex following HTT knockdown
ChIP-seq of HTT protein in mouse cortex following HTT knockdown
PRJNA633501 | ENA
GenomicsTranscriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a
Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a
PRJNA1199444 | ENA
GenomicsHTT regulates muscle differentiation in vitro.
HTT regulates muscle differentiation in vitro.
PRJNA906531 | ENA
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