This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

Serum metabolomic data of Hu sheep collected before and after weaning at 30, 40, and 50 days of age under three weaning strategies: abrupt weaning, single intermittent separation, and two-stage intermittent separation.

Fecal metabolomic data of Hu sheep collected before and after weaning at 30, 40, and 50 days of age under three weaning strategies: abrupt weaning , single intermittent separation, and two-stage intermittent separation .

Background: Hu sheep, renowned for their prolificacy and economic value, have been introduced to Xinjiang for intensive farming operations. However, their suboptimal adaptation to local harsh environments limits growth efficiency and health management. In contrast, Duolang sheep, an indigenous Xi...

HU2014 was inoculated into an optimized medium containing dextrin (39.59 g/L), yeast extract (8.52 g/L), and KNO3 (2.49 g/L), with the initial pH adjusted to 7.0–7.3, and fermented at 25°C and 120 rpm for 15 days. Fermentation supernatants were collected at four time points: day 0 (C0/control), d...

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...