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TranscriptomicsEfficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer
Purpose:Triple negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis with limited therapeutic options. TNBC frequently harbors BRCA mutations translating to platinum sensitivity; platinum response may be augmented by additional suppression of DNA repair mechani...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-55399 | biostudies-arrayexpress
UnknownSelf-powered, light-controlled, bioresorbable platforms for programmed drug delivery.
Not available
S-EPMC10089205 | biostudies-literature
TranscriptomicsSingle-cell RNA-sequencing of immune cells in (1) mouse Renca model treated with anti-CSF1R and (2) mouse MC38 model treated with anti-CD40
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in tumors, but its application towards dissecting mechanisms underlying immune-modulating therapies is scarce. We performed scRNA-seq analyses on immune cells in mouse tumors and identified specific macrophage ...
ORGANISM(S): Mus musculus 
2020-02-23 | E-MTAB-8832 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing (WES) to assess genomic concordance between an adenoma/adenocarcinoma colonoid culture 14-881 and the source patient tissue
A patient-derived epithelium-only colon rectal organoid, also referred to as a colonoid, was generated from an adenoma (associated with a resection surgery of an invasive moderately differentiated colorectal adenocarcinoma) as part of the development of an on-going organoid biobank at the Michigan M...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-9936 | biostudies-arrayexpress
UnknownSuperstable lipid vacuoles endow cartilage with its shape and biomechanics.
Not available
S-EPMC12279017 | biostudies-literature
UnknownA compendium of genetic regulatory effects across pig tissues.
Not available
S-EPMC10786720 | biostudies-literature
UnknownProtein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Not available
S-EPMC6560635 | biostudies-literature
UnknownJoint neutrino oscillation analysis from the T2K and NOvA experiments.
Not available
S-EPMC12545204 | biostudies-literature
UnknownImpact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Not available
S-EPMC5595282 | biostudies-literature
UnknownThe global, regional, and national burden attributable to low bone mineral density, 1990-2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021.
Not available
S-EPMC12623303 | biostudies-literature
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