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MetabolomicsAlterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodbor...
2021-04-13 | MTBLS1918 | MetaboLights
UnknownNetwork Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis.
Not available
S-EPMC9166517 | biostudies-literature
ProteomicsA Quantitative Proteome Map of the Human Body
In this study, we quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-30 | MSV000086387 | MassIVE
UnknownLinked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.
Not available
S-EPMC11324849 | biostudies-literature
MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
UnknownDiverse ancestral representation improves genetic intolerance metrics.
Not available
S-EPMC11920395 | biostudies-literature
UnknownThe Alpha Subunit of Mitochondrial Processing Peptidase Participated in Fertility Restoration in Honglian-CMS Rice.
Not available
S-EPMC10049570 | biostudies-literature
UnknownLipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis.
Not available
S-EPMC6545803 | biostudies-literature
TranscriptomicsDestabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation
HuR promotes myogenesis by stabilizing MyoD, Myogenin and p21 mRNAs during the fusion step of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM...
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-57113 | biostudies-arrayexpress
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